(Brain Tumor; Glioma)
Astrocytoma IDH mutated is a type of brain tumor. An astrocytoma is a type of the larger group of brain tumors called gliomas. Astrocytoma IDH mutated is a tumor whose cells have a mutation in the IDH1 or IDH2 genes.
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Cancer is when cells grow out of control. The cells form a clump of tissue called a growth or tumor. Cancer cells can invade nearby tissues. It can then spread to other parts of the brain and the body. It is not clear exactly what causes these problems.
A person's chances of an astrocytoma IDH mutated could be higher due to:
Tumor growth can make pressure in the brain higher. This may lead to:
- Double vision
- Nausea and vomiting
Symptoms depend on where the tumor is:
- Frontal lobe—Changes in mood and personality, weak muscles on one side of the body
- Temporal lobe—Problems with coordination, speech, and memory
- Parietal lobe—Problems with touch, writing, or fine motor skills
- Occipital lobe—Vision problems and hallucinations
The doctor will ask about symptoms and health history. The answers and a physical exam may raise concern about an astrocytoma.
The doctor may also want to do:
- Imaging tests such as:
- Biopsy/craniotomy—a sample of brain tissue is taken and tested
Astrocytoma IDH mutated are graded from 2 to 4. These grades provide information on how aggressive the tumor is. Grade 4 is more aggressive and can spread to other parts of the brain and spinal cord.
The tumor's location, size, and grade will guide treatment. It may include:
Surgery will remove as much of the tumor as possible.
Radiation therapy uses radiation to kill cancer cells.
Chemotherapy uses drugs to kill cancer cells. It may given by mouth or IV. The drugs enter the bloodstream and travel throughout the body.
There is no way to prevent an astrocytoma IDH mutated since the cause is unknown.
- Adult central nervous system (CNS) tumors treatment (PDQ®)—health professional version. National Cancer Institute website. Available at: https://www.cancer.gov/types/brain/hp/adult-brain-treatment-pdq.
- Astrocytoma and oligodendroglioma in adults. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/Astrocytoma-and-oligodendroglioma-in-adults.
- Astrocytomas. Merck Manual Professional Version website. Available at: https://www.merckmanuals.com/professional/pediatrics/pediatric-cancers/astrocytomas.
- Oligoastrocytoma. American Brain Tumor Association website. Available at: https://www.abta.org/tumor_types/oligoastrocytoma.
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